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Conclusions: Clonazolam concentrations in patient’s blood, measured three times were 0.077 mg/L, 0.015 mg/L, 0.009 mg/L after 4, 8 and 12 h, respectively. Clonazolam’s human toxicity has not been well established, so any case of poisoning should be closely monitored.
Keywords: Blood confirmation; Clonazolam; New designer benzodiazepine.
Diclazepam (Ro5-3448), also known as chlorodiazepam and 2′-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as an unscheduled substance. Efficacy and safety have not been tested in humans.
Metabolism
Metabolism of this compound has been assessed, revealing diclazepam has an approximate elimination half-life of 42 hours and undergoes N-demethylation to delorazepam, which can be detected in urine for 6 days following administration of the parent compound. Other metabolites detected were lorazepam and lormetazepam which were detectable in urine for 19 and 11 days, respectively, indicating hydroxylation by cytochrome P450 enzymes occurring concurrently with N-demethylation.
Formal Name : 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
CAS Number : 2894-68-0
Molecular Formula : C16H12Cl2N2O
Formula Weight : 319.2
Purity : ≥98%
Formulation : A neat solid
Solubility (Learn about Variance in Solubility)
DMF: 30 mg/ml
DMSO: 30 mg/ml
DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
Ethanol: 10 mg/ml
Abstract
Background: Recently the number of new psychoactive substances have significantly increased, becoming popular among experienced users of designer drugs. A significant group includes benzodiazepine derivatives, which have not been introduced as medications but are abused by people experimenting with new and classical psychoactive substances.
Case presentation: The aim of this paper was to present the case of a clonazolam ingestion by a person who was not habituated to benzodiazepines. The intake caused only prolonged coma, decreased muscle tone, and deep tendon reflexes without any other concomitant toxicity and cardio-respiratory failure.
| Grams | 100 grams, 1000 grams, 50 grams, 500 grams |
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